Detecting and Characterizing A-To-I microRNA Editing in Cancer

Adenosine to inosine (A-to-I) editing consists of an RNA modification where single adenosines along the sequence are converted into inosines. Such a biochemical transformation is catalyzed by enzymes belonging family adenosine deaminases acting on (ADARs) and occurs either co- or post-transcriptionally. The employment powerful, high-throughput detection methods has recently revealed that A-to-I widely in non-coding RNAs, including microRNAs (miRNAs). MiRNAs class small regulatory RNAs (ncRNAs) as translation inhibitors, known exert relevant roles controlling cell cycle, proliferation, cancer development. Indeed, growing number recent researches have evidenced importance miRNA biology exploiting various validation methods. Herein, we briefly overview early currently available discuss significance human cancer.